Soukaina

BRAIN R ESEARCH E LSEVIER Brain Research 711 (1996) 163-174 R esearch report E ndotoxin produces a depressive-like episode in rats R az Yirmiya * incision of Psychology, The Hebrew UniL,ersity of Jerusalem, Mount Scopus, Jerusalem 91905, Israel reliable 31 October 1995 A bstract Activation of the immune system produces mental and physiological effects, which jibe the characteristics of depression. The present study was designed to suss out further, in rats, the semblance between the doingsal effects of immune activation and a baffle of depression in animals. decline in the preference for and outlay of saccharin solutions and suppression of sexual behavior were used as models of one inwrought feature of depression, the unfitness to experience pleasure (anhedonia). Other measures interrogatory this model were the decrease in food consumption, body weight, locomotive action mechanism, and brotherly fundamental interaction. It was found that sy stemic injection of lipopolysaccharide (endotoxin), which is a manlike activator of the immune system, significantly lessen saccharin preference in fluid-deprived rats. Lipopolysaccharide (LPS) besides decreased free consumption of saccharin, but not water, in non-deprived rats.

some(prenominal) indices of male sexual behavior were significantly suppress hobby LPS administration. Chronic, but not acute, treatment with the tricyclic antidepressant dose imipramine abolished the restrictive effect of LPS on saccharin preference. Moreover, chronic, but not acute, treatment with imipramine also reduced and facilitated the recovery fro m the restrictive effects of LPS on food c! onsumption, body weight, social interaction and activity in the open-field test. The results suggest that activation of the immune system in rats produces anhedonia and early(a) depressive-like symptoms, which can be attenuated or only block by chronic treatment with an antidepressant drug. Keywords: Lipopolysaccharide; notion;...If you motivation to get a full essay, order it on our website: BestEssayCheap.com

If you want to get a full essay, visit our page: cheap essay